Apply every 7-10 days when insects are present or as needed to prevent further damage. This 32 fl oz container will make 12 gallons of protection for your garden. Since Safer Brand insect killing soap is a contact killer, several applications may be needed for full control. As a general rule, much like watering, do not use these products in the peak of the day or when temperatures exceed 90 degrees F to avoid wilting or browning of the leaves. It breaks down into their natural elements within 7-10 days and will not persist in the environment.